CD274 and neoplasm: However, when HLA-I positive/PD-L1 negative and HLA-I negative/PD-L1 positive cases were analyzed independently, we could see that the average survival time of patients with HLA-I positive/PD-L1 negative tumor was longer (161 months) than that in patients with HLA-I negative/PD-L1 positive tumors (only 54 months) (Log Rank (Mantel-Cox) 5.18; p = 0.023).