Table 1 summarizes different clinicopathologic parameters and different immuno-morphological tumor characteristics, such as HLA-I and PD-L1 expression, T-cell infiltration patterns and tumor encapsulation and distribution of FAP positive stroma cells. Alterations in tumor HLA expression did not show any correlation with the analyzed clinical variables, such as tumor stage, even when we compared T1/Ta (NMIBC) and T2/3(MIBC) tumors (Table 1). This evidence concerns the gene CD274 and neoplasm.