While no significant changes could be observed for the secretion of pro-MMP2 (Figure 6A), the addition of AZA increased the zymographically detectable amount of active MMP-2 ([vs. C] 4-fold; [vs. T] 3-fold; Figure 6B) and the generation of C2C ([vs. T] +0.5 ng/mL) after cartilage trauma. This evidence concerns the gene MMP2 and injury.