Stratification was based on the IHC evaluation of MMR proteins expression (MLH1, MSH2, MSH6 and PMS2), p53 alteration and Epstein–Barr virus early RNA (EBER) antigen presence characterizing the MSI, CIN and EBV subtypes, respectively. This evidence concerns the gene TP53 and cervical squamous intraepithelial neoplasia.