SPTAN1 and neoplasm: Conversely, subgroup analysis of UICC stage III and IV tumours showed improved overall survival in the SPTAN1-high group compared with the SPTAN1-low group (hazard ratio in the SPTAN1-high group, 0.43; 95% confidence interval, 0.21 to 0.90; p = 0.025) (Figure 1c).