CD4 and neoplasm: In fact, HRSCs produce Th-2 and T-reg chemoattractants, including CCL17/TARC, CCL22, CCL5, IL-4, IL-5, IL-10 and IL-13 and induce a functional reprogramming of tumour-infiltrating T cells skewing CD4+ differentiation toward Th-2 and T-reg phenotypes [34,35].