TGFB1 and neoplasm: The M2-like phenotype is often associated to protumour functions: in fact, these cells produce and release cytokines (IL-6) and growth factors (EGF, FGF, VEGF, PDGF and TGF-β), which stimulate proliferation and increase resistance to the apoptosis of tumour cells, activate fibroblasts and trigger angiogenesis.