Moreover Ferrarini et al. found that HRS and surrounding T lymphocytes stained positive for IL-17 in 40% of cases and that the coculture of cHL cell lines with peripheral blood mononuclear cells promoted the enrichment of Th17 lymphocytes and FOXP3+/IL-17+ cells: these observations suggest the existence of an IL-17 tumour-shaped inflammatory milieu, at least in the subset of cHL cases [39]. This evidence concerns the gene IL17A and classic Hodgkin lymphoma.