Among other co-mutations, the CTNNB1 mutation was an independent risk factor (hazard ratio 8.65; 95% confidence interval 3.0–24.9; p < 0.001) and TP53 (hazard ratio 3.48; p = 0.02) was a risk factor for recurrence in patients with stage IB–IIIA cancer (Table 2). The gene discussed is CTNNB1; the disease is cancer.