CTNNB1 and hepatocellular carcinoma: As shown in Table 4, of three the patient with HCC with iso-high intensity in the hepatobiliary phase of EOB-MRI, two (66.7% 2/3) showed CTNNB-1 alterations (case 1; CTNNB-1 T41A, variant frequency 30/13,721; CTNNB-1 S45F, variant frequency 28/13,723, case 2; CTNNB-1 T41A, variant frequency 196/12,329) in cfDNA.