Since our previous results demonstrated a reduction in LPHN1 levels in AML cells expressing ABCB1, we further focused on the detection of GAL-9 (LGALS9) and TIM-3 (HAVCR2) expression in SKM-1 and MOLM-13 cells and in their ABCB1-positive variants resistant to VCR, (SKM-1/VCR and MOLM-13/VCR). This evidence concerns the gene LGALS9 and acute myeloid leukemia.