TP53 and hepatocellular carcinoma: Further, although there are no available data about the role of BMAL1 in the HCC development, it has been demonstrated that one isoform of the tumor suppressor HNF4a, which was induced in some forms of HCC, can repress BMAL1 expression, and that forced expression of BMAL1 in HFN4a-positive HCC prevents the growth of tumors in vivo by stimulating p53 expression and the activation of apoptosis [97].