We chose the following cell lines: non-small cell lung cancer (NSCLC) EIH1299-R273H cell line that is inducible for p53 R273H expression, gallbladder cancer cells G-415, in which we found a p53 R282W mutant (G-415-R282W) and pancreatic ductal adenocarcinoma (PDAC) Panc-1 cells that endogenously express p53 R273H (Panc-1-R273H), all belonging to aggressive tumors [19,51,52]. The gene discussed is TP53; the disease is pancreatic ductal adenocarcinoma.