The anti-tumor role of inflammasomes has been extensively studied in colitis-associated cancer, showing that the secretion of IL-18 mediated by the NLRP3 inflammasome could protect enterocytes from early-stage colitis induced by dextran sulfate sodium (DSS) or azoxymethane (AOM) [52,56,57,58] (Table 1). This evidence concerns the gene NLRP3 and cancer.