It is of major interest that in vitro functional analysis in human liver cancer cell lines demonstrated that knockdown of CNPY2 inhibited cell growth, survival and proliferation due to suppression of cyclin D1, induction of cyclin-dependent kinase inhibitor p21Waf1/cip1 and downregulation of the apoptosis inhibitor Bcl2 [12]. The gene discussed is CDKN1A; the disease is liver cancer.