SEPTIN9 and hepatocellular carcinoma: In rats, CK8/18 overexpression in the cytoplasm of liver preneoplastic cells was accompanied by increase in cell proliferation, elevation of histone type 2 H2aa3, mitochondrial prohibitins 1 (PHB1) and 2 (PHB2) and septin 9 (SEPT9), and serve as an indicator of transformation of GST-P+ foci into HCC [7].