CNPY2 increase in AF and liver tumors was closely associated with elevation of numerous cytoskeletal proteins such as actins alpha 1 (ACTA1) and gamma 2 (ACTG2), non-muscle myosin, heavy chain 9 (MYH9), tropomyosin 3 (TPM3), septin 9 (SEPT9), plectin (PLEC), cytokeratins 8 (CK8) and 18 (CK18), tubulin, beta 2C (TUBB2C) and fibronectin 1 (FN1), and upregulation of calreticulin (CALR), prohibitins 1 (PHB1) and 2 (PHB2), and YME1-like 1 (YME1L1), participating in regulation of transcription, and ER and mitochondrial stresses. Here, SEPTIN9 is linked to atrial fibrillation.