The involvement of the TNF-α and MMP-9/TIMP-1 complex in radiation-induced non-targeted effects led to the inhibition of tumor angiogenesis, highlighted by the 0.34-fold decrease in the MMP-9/TIMP-1 ratio in patients without AIT, which was only 0.8-fold in patients with coexisting AIT. The gene discussed is TNF; the disease is neoplasm.