A group of bromodomain protein genes are consistently highly expressed across several different tumor types, including ATAD2, KAT2A, bromodomain and WD repeat domain containing 3 (BRWD3), Tripartite motif 28 (TRIM28), SWI/SNF related, matrix associated actin dependent regulator of chromatin, subfamily A, member 4 (SMARCA4), BRD9, and bromodomain adjacent to zinc finger domain 1A (BAZ1A). The expression of several of these genes has previously been documented in different cancers. This evidence concerns the gene BRWD3 and cancer.