MUC1 was shown to induce BRN2, an NEPC-associated transcription factor, through MYC-mediated mechanism, and silencing MUC1 caused suppression of BRN2.This study highlights the significance of MUC1 in prostate cancer lineage plasticity, making it an attractive target for therapeutic inter-vention. Here, POU3F2 is linked to Familial prostate cancer.