FLT3 and myelodysplastic syndrome: Adverse prognostic factors include an advanced age, high WBC count at diagnosis, history of myelodysplastic syndrome (MDS) or chronic myeloproliferative neoplasm (MPN), cytogenetic alterations such as deletion of chromosome 5 and/or 7 and molecular aberrations such as Fms-related receptor tyrosine kinase 3 (FLT3) mutations [57].