KRAS and TP53 are the most frequently mutated genes in NSCLC [7,8]; in this conditional model, the activation of oncogenic Kras and the deletion of Tp53 can be induced in the lungs by inhalation of adenoviral particles expressing Cre recombinase (AdenoCre, Viral Vector Core Facility, University of Iowa, Iowa City, IA, USA). Here, TP53 is linked to non-small cell lung carcinoma.