The host immune response seems to play a key role in tumor spreading and progression: the number of circulating activated neutrophils increases in the presence of a tumor and the resulting inflammatory state promotes tumor proliferation and neo-angiogenesis, mediated by Vascular Endothelial Growth Factor (VEGF) [26]; furthermore, neutrophilia can inhibit the adaptive immune response, mediated by lymphocytes [27]. This evidence concerns the gene VEGFA and neoplasm.