RUNX1 and chronic myelogenous leukemia, BCR-ABL1 positive: Conversely in CML, the natural course of which is transformation into acute leukemia, only some of these mutations are detected (e.g., RUNX1 or ASXL1), and they are present only in about half of patients with BC-CML, and in a minority of patients with CP-CML [31,32,33,59,61].