RUNX1 and acute myeloid leukemia: In AML, various mutations in genes involved in the development of myeloid malignancies and constituting predisposition factors (e.g., CEBPA, GATA2, RUNX1, ANKRD26, ETV6, ASXL1) have been identified, particularly from the study of hereditary diseases, familial forms, and karyotypic abnormalities [60].