PDK1 mRNA expression was upregulated in PCa compared to the adjacent prostate gland in two independent datasets: Arredounai (adjacent prostate gland (n = 8), prostate cancer (n = 13)) and Lapointe (adjacent prostate gland (n = 39), prostate cancer (n = 57)) (Figure 1A). This evidence concerns the gene PDK1 and Familial prostate cancer.