TQ concomitantly increased the activated caspase-9 level and decreased the pro-caspase-3 and -9 levels in parallel with cytochrome c release, which occurred early and prominently in WSU-NHL and SUDHL-4 cells, but manifested later and less impressively in HT cells (Figure 2d–e). Here, CASP3 is linked to non-Hodgkin lymphoma.