UT cells constitutively express cytokine receptors and can rapidly respond to various cytokines produced by activated dendritic cells (DCs), macrophages, neutrophils, epithelial/endothelial/stromal cells or infected/tumor cells, including IL-12, IL-1β, IL-18, IL-23, IL-7, IL-15 and type I IFNs (see [52,53,60,61] for reviews). This evidence concerns the gene IL1B and neoplasm.