Abbreviations: CHOP: cyclophosphamide, doxorubicin, vincristine, and prednisone; HR+: hormone receptor positive; HER2−: human epidermal growth factor 2 negative; CRPC: castration resistant prostate cancer; SCLC: small cell lung cancer; AML: acute myelodysplastic leukemia; MDS: myelodysplastic syndrome; DLBCL: diffuse large B-cell lymphoma; HGG: high grade glioma. The gene discussed is ERBB2; the disease is central nervous system cancer.