TP53 and cancer: Examples of population studies observe the activation of oncogenic routes such as Kirsten rat sarcoma viral oncogene homolog gene (KRAS) [252], tumor suppressor genes adenomatous polyposis coli (APC) and TP53 [13,253], cyclin D1 (CCND-1), or matrix metalloprotease 2 (MMP2) [254], in different cancers types influenced, at least in part, by alcohol consumption [255].