The occurrence of single nucleotide variants rs738409 in the PNPLA gene and rs58542926 in transmembrane 6 superfamily member 2 gene (TM6SF2) associate with the risk of hepatocellular carcinoma, whereas variant rs4607179 of hydroxysteroid 17-beta dehydrogenase gene (HSD17B13) reduces the risk [213]. This evidence concerns the gene HSD17B13 and hepatocellular carcinoma.