CTLA4 and non-small cell lung carcinoma: Very recently, the FDA also approved the combination of nivolumab and ipilimumab (the cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) inhibitor) as the first-line treatment for certain patients with metastatic or recurrent NSCLC, with no EGFR or anaplastic lymphoma kinase (ALK) genomic tumor aberrations [17].