Pancreatic cancer screening recommendations are discussed if a PV is identified in a pancreatic cancer gene (ATM, BRCA1, BRCA2, CDKN2A, MLH1, MSH2, MSH6, EPCAM, PALB2, STK11, and TP53) in a patient with a family member (first or second degree) with a history of pancreatic cancer [157]. This evidence concerns the gene MSH6 and pancreatic neoplasm.