The epigenetic signatures of ATM, BRCA1, PALB2, RAD51B, and XRCC3 have also been explored in MBC (32.4% with germline BRCA2 PV) in matched normal and gynecomastia tissue samples (obtained from patients without cancer or a family history of BC) [76]. This evidence concerns the gene XRCC3 and Gynecomastia.