It has also been previously reported a higher incidence of BC in Jewish men (2.3/100,000 per year), for whom the spectrum of germline PVs in BRCA1 and BRCA2 (BRCA1/2) encloses few predominant and recurrent PVs, both in Jewish Ashkenazi and in non-Ashkenazi [22,23,24,25]. Here, BRCA2 is linked to breast cancer.