CHIP is an optional preneoplasia, and is correlated with the development of hematological neoplasms with a probability of 0.5 to 1% per year, especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), depending on the clone size, number of mutations and affected genes [26,27]. This evidence concerns the gene STUB1 and myelodysplastic syndrome.