CHIP is an optional preneoplasia, and is correlated with the development of hematological neoplasms with a probability of 0.5 to 1% per year, especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML), depending on the clone size, number of mutations and affected genes [26,27]. The gene discussed is STUB1; the disease is acute myeloid leukemia.