Due to the overlapping mutational and expression profile of CNL and aCML, and to a lesser extent chronic myelomonocytic leukemia (CMML) and MDS/MPN unclassifiable, and their association with CHIP, it has recently been suggested that these entities might represent a continuum of closely related hematological disorders rather than discrete entities [16]. This evidence concerns the gene STUB1 and chronic myelomonocytic leukemia.