Remarkably, it has been reported since 2014 that invasive multi-bacterial biofilms were detected in 89% of right-sided CRC (RCC) but in only 12% of left-sided CRC (LCC) and the former were related to aggravated crypt epithelial cell proliferation in normal colon mucosa, diminished intestine epithelial cell line E-cadherin, increased epithelial permeability, and enhanced activation of IL-6 and STAT3 [68]. This evidence concerns the gene STAT3 and colorectal carcinoma.