Almost half of glioma patients show a B cell tumor infiltration that is distinguished by (i) immunosuppressive activity towards cytotoxic T cells, (ii) overexpression of inhibitory molecules PD-L1 and CD155, and (iii) production of immunosuppressive cytokines, such as TGF-β and IL-10 [159,160]. Here, CD274 is linked to central nervous system cancer.