To study the role of the VCAM-1-binding integrin VLA-4 and fibronectin-binding integrin VLA-5 in chemoresistance of T-ALL cells, we assessed the apoptotic response to doxorubicin of Jurkat and HSB-2 cells adhering on VCAM-1 and fibronectin. The gene discussed is VCAM1; the disease is acute lymphoblastic leukemia.