To study the role of the VCAM-1-binding integrin VLA-4 and fibronectin-binding integrin VLA-5 in chemoresistance of T-ALL cells, we assessed the apoptotic response to doxorubicin of Jurkat and HSB-2 cells adhering on VCAM-1 and fibronectin. Here, ITGA5 is linked to acute lymphoblastic leukemia.