Recently, studies from our group and others have shown that serum cartilage oligomeric matrix protein (COMP) and Golgi protein-73 (GP73) levels were positively correlated with indices of progression of chronic liver diseases, such as inflammatory activity, fibrosis/cirrhosis, and HCC [16,17,18,19,20,21,22,23,24,25]. Here, COMP is linked to hepatocellular carcinoma.