COMP and Cirrhosis: Furthermore, the combination of GP73, COMP, APRI, and FIB-4 had the highest diagnostic accuracy to detect the presence of cirrhosis [AUC (95% CI): 0.916 (0.878–0.946)] than each marker alone: GP73 [AUC (95% CI): 0.843 (0.795–0.883); P < 0.001], COMP [AUC (95% CI): 0.770 (0.716–0.817); P < 0.001], APRI [AUC (95% CI): 0.833 (0.784–0.874); P < 0.001], and FIB-4 [AUC (95% CI): 0.885 (0.846–0.920); P = 0.02] (Figure 2).