Of note, among 229 non-HCC patients at baseline who were followed, the AFP positivity showed a 41% sensitivity, 91% specificity, 42% positive predictive value, and 90% negative predictive value for HCC development during follow-up while the respective indices of triple seropositivity for COMP, GP73, and AFP were 13%, 99%, 67%, and 87%. Here, COMP is linked to hepatocellular carcinoma.