The comparison of patients with increased AFP (>10 ng/mL) to those with normal levels (≤10 ng/mL) did not show any significant difference in the diagnostic accuracy of the GP73 and COMP combination for the detection of cirrhosis [AUC (95% CI): 0.835 (0.688–0.981) vs. 0.864 (0.812–0.917); P = 0.713], severe fibrosis (≥F3) based on liver biopsy [AUC (95% CI): 0.854 (0.661–1.047) vs. 0.760 (0.678–0.843); P = 0.382], or severe fibrosis (≥F3) based on TE measurements [AUC (95% CI): 0.778 (0.490–1.066) vs. 0.801 (0.721–0.881); P = 0.880]. Here, AFP is linked to Cirrhosis.