A large international prospective cohort study involving over 3000 patients recently found cumulative incidence of CRC (at 75 years) of 46%, 35%, 49%, and 10% for MLH1, MLH2, MSH6, and PMS2 mutation carriers, respectively, after a mean follow-up period of 7.8 years [47]. The gene discussed is PMS2; the disease is colorectal carcinoma.