TP53 and neoplasm: In contrast, a separate study reported that PALB2-associated mammary tumorigenesis was delayed upon autophagy impairment through monoallelic loss of Becn1, in the context of normal TP53 but not under conditions of conditional TP53 silencing, suggesting that loss of TP53 expression may override or compensate for the reduced fitness in autophagy-impaired tumor cells [181].