BRAF and hairy cell leukemia: However, BRAF is also frequently mutated in numerous different cancer types, including ~100% of hairy cell leukemia, 50% of melanoma, 20–40% of thyroid carcinoma, 10–15% of colorectal adenocarcinoma, 10% of glioblastoma, 4% of non-small-cell lung cancer, and small percentages of non-Hodgkin’s lymphoma, multiple myeloma, and ovarian cancer [2,3,4,5,6,7].