Furthermore, Ligorio et al., (2019) reported that CAF-derived TGF-β can drive the expansion of a highly proliferative PDAC tumor cell subpopulation that can readily undergo epithelial-to-mesenchymal transition (EMT) arguing for a pro-tumorigenic role of TGF-β signalling in PDAC [86]. The gene discussed is TGFB1; the disease is neoplasm.