TP53 and pancreatic neoplasm: Likewise, Novo et al., (2018) reported that pancreatic cancer cells with a mutant p53 phenotype can activate fibroblasts to be pro-invasive via exosomal secretion of a sialylated glycoprotein called podocalyxin (PODXL), while p53 null-derived exosomes could not [75] (Figure 2b).