Energy stress is responsible for changes in lncRNA expression; for example, the lncRNA NBR2 (neighbor of BRCA1 gene 2) is induced by the liver kinase B1 (LKB1)/AMP-activated protein kinase (AMPK), a critical sensor of the cellular energy status; interestingly, the knockdown of NBR2 results in uncontrolled cell cycle progression and enhanced tumor growth (Figure 1); in agreement with this, low NBR2 expression is an indicator of poor prognosis in several human cancers [16]. The gene discussed is STK11; the disease is cancer.