MYC and cancer: The crosstalk between lncRNAs and cellular metabolism also has important implications in cancer progression; for example, the lncRNA-21 is positively regulated by c-Myc and HIF-1α, two transcription factors with a key role in glucose metabolism; lncRNA-21, in turn, binds to HIF-1α preventing its degradation and leading to hypoxia-enhanced glycolysis [20] (Figure 1).