Among clinically relevant lncRNAs, the HIF-1α anti-sense lncRNA (HIFAL) plays a critical role in the transactivation of hypoxia-inducible factor-1 α (HIF-1 α), a master regulator of glucose metabolism in cancer cells; HIF-1α, in turn, induces HIFAL transcription, whose expression promotes tumor growth and is associated with an aggressive phenotype and poor outcome in breast cancer patients [60]. This evidence concerns the gene HIF1A and neoplasm.