In lung cancer, the metastasis process has been associated with the expression of the insulin-like growth factor binding protein 4–1 (IGFBP4–1) lncRNA, through a mechanism of metabolic reprogramming; lnc-IGFBP4–1 up-regulation promotes cell proliferation and the transcription of LDHA, HK2 and PDK1, influencing energy production [50]. This evidence concerns the gene IGFBP4 and lung carcinoma.