PKM2 directly interacts with the TGF (transforming growth factor)-β-induced factor homeobox 2 (TGIF2) in the nucleus of colon cancer cells, recruiting histone deacetylase 3 to the E-cadherin promoter and leading to the suppression of E-cadherin transcription and favouring epithelial-mesenchymal transition (EMT) [17]. Here, CDH1 is linked to malignant colon neoplasm.