HK2 and hepatocellular carcinoma: In hepatocellular carcinoma (HCC), the lncRNA TUG1 regulates the expression of miR-455-3p, which targets the adenosine monophosphate-activated protein kinase subunit β2 (AMPKβ2), involved in the regulation of HK2; TUG1 is strongly associated with HK2 overexpression, enhanced glycolysis and cell migration, and represents an indicator of poor prognosis in HCC [40].