AKT1 and hepatocellular carcinoma: In cervical cancer, for example, MALAT1 overexpression promotes the development of cisplatin resistance via the PI3K/AKT signaling pathway [63], while in hepatocellular carcinoma (HCC), the long noncoding RNA CRNDE (colorectal neoplasia differentially expressed) has been correlated with poor clinical outcome and chemoresistance by inhibiting the tumor suppressor genes CUGBP Elav-like family member 2 (CELF2) and large tumor suppressor 2 (LATS2) [64].