In partial congruence with our findings, Khvostova et al. reported that, compared to normal adjacent prostate tissues, the expression of HSD17B3 and SRD5A2 was markedly increased in benign prostatic hyperplasia (BPH) tissues, HSD17B2 expression was significantly decreased in all samples, and SRD5A2 transcript level was upregulated in BPH and PCa compared to the normal adjacent prostate tissues [23]. This evidence concerns the gene HSD17B3 and benign prostatic hyperplasia.