Furthermore, molecular docking shows that the HSD17B2/HSD17B3 complex (docking score = −359.46; ligand root-mean-square deviation, RMSD = 49.54 Å) directly interacts with the SRD5A1/SHBG complex (docking score = −296.02; ligand RMSD = 69.47 Å) to form a HSD17B2/HSD17B3/SHBG/SRD5A1 macro-complex (docking score = −355.07; ligand RMSD = 114.28 Å), posited herein to drive the androgenic cum recurrent phenotype of patients with PCa (Figure 4C). Here, HSD17B3 is linked to posterior cortical atrophy.