In concordance with our findings that a high SRD5A1/SHBG ratio is associated with upregulated drug efflux proteins ALDH1A1, ABCB1, ABCC1, ABCG2, and markers of pluripotency, including KLF4, LIN28, OCT4, and SOX2, there are reports implicating enhanced drug-efflux in the resistance of CRPC to many chemotherapeutics, including Docetaxel, a drug of choice for hormone-naïve advanced PCa in conjunction with ADT [27]. Here, SOX2 is linked to posterior cortical atrophy.