Furthermore, using samples from our PCa cohort (n = 56), compared to the moderate-strong immunoreactivity of HSD17B3 and SRD5A1 in high-grade PCa (Gleason score (GS) ≥ 8), normal prostate tissue (GS ≤ 5), and low-grade PCa (GS = 6–7) were characterized by null-mild protein expression, conversely, moderate-strong HSD17B2 and SHBG protein expression levels were observed in the normal prostate and low grade PCa tissues compared to null–mild protein expression in the high-grade samples (Figure 1C). Here, HSD17B3 is linked to posterior cortical atrophy.