Furthermore, AFFY_HG_U133_PLUS_2 expression profiling array analysis of the stromal molecular signatures of prostate and breast cancer using the GSE26910 dataset (n = 24) showed that, compared to downregulated SHBG, HSD17B2 and HSD17B3 expression, upregulated expression of SRD5A1 in tumor samples positively correlated with upregulation of ATP-binding cassette subfamily C member 1/multidrug resistance-associated protein 1 (ABCC1/MRP1), multidrug resistance protein 1 (ABCB1/MDR1) (Figure 4D), NANOG, SOX2, and POU Class 5 Homeobox 1 (POU5F1/OCT4) (Figure 4E). The gene discussed is SHBG; the disease is breast cancer.