We posit that the withdrawal of SRD5A1 or induction of SHBG in aggressive PCa cells elicits “oncogenic shock” [33], which entails the death of the testosterone tetrad-addicted cancerous cells upon inhibition of the oncoprotein SRD5A1 to which they are seemingly addicted, or ectopic expression of the tumor suppressor SHBG to which they were estranged. The gene discussed is SRD5A1; the disease is posterior cortical atrophy.