The association of increased SRD5A1/SHBG ratio with upregulated expression of stemness markers LIN28, NANOG, KLF4, OCT4, and SOX2 is therapeutically relevant in terms of cancer stem-cell-targeting strategy, as it suggests an alternative approach to inhibiting signaling that are essential for the homeostasis and function of cancer stem cells, which are well documented drivers of cancer progression. The gene discussed is SOX2; the disease is cancer.