BCR and posterior cortical atrophy: Interestingly, accruing evidence indicate that “PSA screening does lead to over-diagnosis, over-treatment, and treatment-associated morbidity” [38], and, consistent with the European Association of Urology (EAU) PCa guidelines panel recommendations, the PSA-based “BCR after primary treatment of localized prostate cancer does not necessarily lead to clinically apparent progressive disease” [39].