SHBG and posterior cortical atrophy: We posit that the withdrawal of SRD5A1 or induction of SHBG in aggressive PCa cells elicits “oncogenic shock” [33], which entails the death of the testosterone tetrad-addicted cancerous cells upon inhibition of the oncoprotein SRD5A1 to which they are seemingly addicted, or ectopic expression of the tumor suppressor SHBG to which they were estranged.