More so, using the GSE3325 dataset (n = 19), we observed markedly upregulated SRD5A1, HSD17B2, POU5F1, SOX2, and NANOG in the metastatic PCa, and HSD17B3, CD44, POU5F1, ABCB1, prominin 1 (PROM1/CD133), ABCC1, NANOG, and Kruppel-like factor 4 (KLF4) in primary PCa (Figure 4G). Here, HSD17B3 is linked to posterior cortical atrophy.