We observed strong association between high HSD17B2/SRD5A1 expression and metastasis to distant lymph nodes (M1a) and bones (M1b) in patients with PCa, while high HSD17B3/SHBG expression correlated more with negative metastasis status (M0) (Figure 3A). This evidence concerns the gene SRD5A1 and posterior cortical atrophy.