SRD5A messenger RNA expression profiling in several publicly available cancer datasets show that, compared with nontumor prostate tissues, SRD5A1 is upregulated in primary and metastatic PCa, and the activation of the driver oncogene androgen receptor (AR) induced a 2- to 4-fold overexpression of SRD5A1 in androgen-responsive PCa cells [5]. The gene discussed is SRD5A1; the disease is cancer.