These data demonstrate that the concerted (but not individual) activity of the tetrad exhibited a high prognostic index, indicating that the differential expression pattern of the HSD17B2/HSD17B3/SHBG/SRD5A1 tetrad in androgen-addicted PCa has prognostic implications relevant for prediction of the clinical outcome. Here, SRD5A1 is linked to posterior cortical atrophy.