PPARGC1A and hepatocellular carcinoma: Studies on HCC phenotypes detected elevated O-GlcNAc levels for certain proteins that profoundly affect hepatocarcinogenesis, such as PGC1α (peroxisome proliferative-activated receptor gamma coactivator 1 alpha) [9], c-MYC [10], and RACK1 (ribosomal receptor for activated C-kinase 1) [11].