While in a physiological context, when the collagen I network is crosslinked, fibronectin fibers are relaxed and fibroblasts resume their quiescence [15], in a tumor context, the ECM remodeling is continuous [19,20,21], altering the distribution of fibronectin zones by preventing the relaxation of fibronectin fibers [22]. This evidence concerns the gene FN1 and neoplasm.