Such matrix organizational changes are dependent on ECM composition modification [158], on integrin engagement [150], on expression of specific peptidase such as FAP (fibroblast activation protein) [157], and on actomyosin-dependent contractility of cells (CAFs and tumor cells) that allow to modify the alignment of ECM fibers [112,159,160,161,162,163]. The gene discussed is FAP; the disease is neoplasm.