Indeed, Bever et al., using computer-aided quantitative method to correlate patient survival with stroma density and activity in pancreatic cancer, observed that high stromal density (ratio of the stroma area to total tumor area), but not stroma activity (measured by α-SMA expression), was significantly associated with longer disease-free survival (DFS) and overall survival (OS) in a cohort of 66 PDAC patients (who underwent pancreaticoduodenectomy and received adjuvant therapy) [40]. This evidence concerns the gene ACTA1 and neoplasm.