Through the analysis of our previously described pediatric AML cohort gene expression signature (n = 71, GSE75461 [30]: NPM1 mutations n = 4, MLL-translocations n = 7, NUP98-rearrangements n = 19, no molecular marker n = 21, CBF rearrangements n = 20), we documented that HOXA family genes were overexpressed in NPM1-mutated cells, as well as in MLL-translocated and NUP98-rearranged AML blasts. This evidence concerns the gene KMT2A and acute myeloid leukemia.