HOXA family genes resulted highly expressed in MLL-translocated, NUP98-rearranged, and NPM1-mutated AML as expected, whereas HOXB genes were mostly upregulated in NUP98-rearranged and NPM1-mutated AML (Figure 2B, Supplemental Figure S2). This evidence concerns the gene KMT2A and acute myeloid leukemia.