HOXA family genes resulted highly expressed in MLL-translocated, NUP98-rearranged, and NPM1-mutated AML as expected, whereas HOXB genes were mostly upregulated in NUP98-rearranged and NPM1-mutated AML (Figure 2B, Supplemental Figure S2). The gene discussed is NPM1; the disease is acute myeloid leukemia.