(Table 3) On multivariable analysis, there was no longer significant difference between post-SVR HCC vs. viremic HCC in association to survival after adjustment for potential confounders, while the presence of liver cirrhosis, higher AST, ALT, creatinine, AFP, BCLC stage 0/A, and curative therapy were independently associated with overall survival. The gene discussed is AFP; the disease is hepatocellular carcinoma.