CD4 and breast cancer: For example, collaboration between T and B cells to carry out eradication of tumor cells, which may be related to CD4+ T cells (identified as the third most influential TME features on breast cancer prognosis from the EPIC, CIBERSORT, TIMER, and xCell XAI analyses in Figure 2) causing B cells to proliferate and their progeny to differentiate into antibody-secreting cells [56].