At this point, the sonic hedgehog (SHH) subgroup is the population of choice for a personalized targeted intervention in adults with medulloblastoma, as this subgroup constitutes the majority of adult patients (60–70%) [11,63], and specific inhibitors of smoothened (SMO), an upstream member of the SHH signaling pathway, are available. The gene discussed is SMO; the disease is medulloblastoma.