The tumor suppresser, 12-O-Tetradecanoyl phorbol-13-acetate (TPA)-inducible sequences 21 (TIS21), an ortholog of B-cell translocation gene 2 (BTG2), inhibited TNBC cell growth and invasion via activation of Akt1 and not Akt2 [169]. The gene discussed is AKT2; the disease is neoplasm.