TSC2 and neoplasm: Ablation of Akt1 in mice not only inhibited ErbB2-induced mammary tumorigenesis and delayed tumor growth by inhibiting phosphorylation of TSC2 at Ser-939, but also decreased lung metastases and reduced migration of mammary epithelial cells both in 2D and 3D cell culture via induction and secretion of CXCL16 [99].