Knockdown of Akt1 inhibited invasion of IBC cells by inhibiting phosphorylation of RhoC GTPase, a substrate for Akt1, but had no effect on non-IBC (nIBC) cells whereas Akt2 knockdown inhibited invasion of nIBC cells but had no effect on the invasiveness of IBC cells [102]. This evidence concerns the gene RHOC and inflammatory breast carcinoma.