Here, we describe the generation and characterization of a new mouse model obtained by combining doxycycline-inducible expression in the lung of the human EGFRT790M/L858R oncogene, which promotes the development of EGFR-driven lung cancer when expressed alone [6], and wild type human MET, using a transgenic mouse model that promotes liver carcinoma when a liver-specific promoter is used [7]. The gene discussed is MET; the disease is hepatocellular carcinoma.