This mouse model relies on the same doxycycline-inducible genetic system used in the EGFRT790M/L858R transgenic mouse strain that we previously crossed with the lung-specific CCSP-rtTA strain (EGFRT790M/L858R/rtTA, EGFR mice hereafter) and in which EGFR-driven lung adenocarcinoma appears upon doxycycline exposure [6]. The gene discussed is EGFR; the disease is lung adenocarcinoma.