AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: To date, it is reportedly known that several signaling pathways maintain the self-renewal capacity in CML stem cells, such as JAK/STAT, Hedgehog, Wnt/β-catenin, PI3K–Akt and TGF-β-FOXO signaling within the bone marrow microenvironmental niche [6,7,8].