Levels of phospho-Akt and phospho-S6 were increased in Gdpd3-deficient LT-CML stem cells compared to WT-LT-CML stem cells, indicating that Gdpd3 loss activates the Akt–mTORC1 signaling pathway in CML stem cells. The gene discussed is GDPD3; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.