AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: Our investigation revealed that lysophospholipid metabolism inhibits Akt, and that it is the lysophospholipase D enzyme Glycerophosphodiester Phosphodiesterase Domain Containing 3 (Gdpd3) that plays an essential role in maintaining stem cell quiescence and TKI resistance in CML stem cells [14,15].