Among these GPCR genes, mRNA levels of the Lgr4/GPR48 gene, which encodes a leucine-rich repeat (LRR)-containing GPCR, were decreased in Gdpd3-deficient LT-CML stem cells compared to WT-LT-CML stem cells. This evidence concerns the gene LPAR3 and chronic myelogenous leukemia, BCR-ABL1 positive.