ORAI1 and glioblastoma: Specifically, SKF-96365 and YM-58483 displayed dramatic effects in nearly all GBM cultures, whereas GSK-7975A, which preferentially targets the Orai family [26], exerted less pronounced effects (Figure 4B SPHERES I), implying that TRPC1, in conjunction with Orai1, may contribute to the effects of SOC in GSC.