STAT3 and hepatocellular carcinoma: In another study using HCC rats, regular physical activity increased phosphatase and tensin homolog deleted from chromosome 10 (PTEN) expressions and adenosine monophosphate-activated protein kinase (AMPK) phosphorylation while decreasing the phosphorylation of protein kinase B, S6 ribosomal protein, and signal transducer and activator of transcription-3 (STAT-3) [16].