Similarly, in vitro and in vivo results obtained from a former study indicated that the sensitization of curcumin-treated breast cancer cells to paclitaxel and cyclophosphamide was mediated through the inhibition of NF-κB (p50 and p65), protein kinase C (PKC), histone deacetylase (HDAC), and telomerase activity in MDA-MB-231 cells and a breast cancer mouse model [121]. The gene discussed is RELA; the disease is breast carcinoma.