It was shown that curcumin increased cleaved PARP, cleaved caspase-3, cleaved caspase-7, cleaved caspase-9, caspase-3, caspase-8, cytochrome-c, Bax, and Bid expression and decreased Bcl-2, Mcl-1, and Bcl-xL expression, which resulted in apoptosis induction in MDA-MB-231 cells and tumor growth inhibition in an in vivo xenograft model [142,195,196,197]. Here, CASP3 is linked to neoplasm.