HIF1A and metastatic malignant neoplasm in the lymph nodes: Finally, another meta-analysis based on 30 NSCLC studies reported that HIF-1α expression was higher in the presence of lymph node metastasis (OR = 3.72; p < 0.0001), poor degrees of differentiation (OR = 2.12; p < 0.0001), or SqCC histology in comparison to AC (OR = 1.28; p = 0.03) [47].