TWIST1 and lung cancer: In the context of lung cancer, mesenchymal markers such as vimentin, and EMT transcription factors such as TWIST1 (Twist family BHLH transcription factor 1) or Snail were found overexpressed in hypoxic lung specimens while epithelial markers such as E-cadherin were repressed compared to non-hypoxic samples [64,65,66,67,68,69].