Interestingly, there were two carriers of the same PV in TP53 (NM_000546.6), namely c.638G > A; p.Arg213Gln or c.685T > C; p.Cys229Arg, among the BC cases, where the latter PV was identified in cases not known to be related to each other [41,112]. Here, TP53 is linked to breast cancer.