Estimates of the absolute risk for OC in carriers of RAD51C or RAD51D PVs are greater than 10% [7], which is in line with established cancer predisposing genes conferring a significant risk of cancer, as for carriers of PVs in BRCA1 and BRCA2. The relative risk for OC is estimated to be as high as 40% if carriers of variants in these genes have a first-degree relative with OC [117]. The gene discussed is BRCA1; the disease is cancer.