Complex and difficult to detect large deletions or genomic rearrangements in BRCA1 and BRCA2, which are rarely found in the general population, are also likely rare in FCs, as suggested by a study of BC and OC cases from cancer families that applied the established multiplex ligation probe amplification (MLPA) analysis technique and found no examples of carriers of such variants [107]. This evidence concerns the gene BRCA1 and breast cancer.