Since the initial reports of BRCA1 and BRCA2 PVs in FCs, the spectrum of frequently occurring variants identified in FC BC and/or OC cases has expanded to a total of 25 variants, including 18 PVs [35,39,63,80,81,82,83,85,86,87,88,89,90,91] (Table 1, Figure 3, Table S2), of which the majority are nonsense and frameshift variants that are expected to result in the loss of the protein function. The gene discussed is BRCA1; the disease is breast cancer.